Target intelligence / Profile preview

Proliferating Cell Nuclear Antigen (PCNA)

Target: PCNA
Molecular classification: DNA Clamp, Replication Factor

Overview

Proliferating cell nuclear antigen (PCNA) is a highly conserved protein found in the nuclei of eukaryotic cells and archaea. It functions primarily as a DNA clamp, acting as a processivity factor for DNA polymerase δ during DNA replication. PCNA forms a homotrimeric ring that encircles DNA, serving as a scaffold to recruit and coordinate various proteins involved in essential cellular processes such as DNA replication, repair, chromatin remodeling, epigenetic regulation, and cell cycle control. It is also explored as an anti-cancer drug target.

Mechanism of action

Disruption of PCNA interactions or function using small molecules or peptides.

Biological functions

DNA ReplicationDNA RepairChromatin RemodelingEpigenetic RegulationCell Cycle ControlSister Chromatid Cohesion

Disease associations

Cancer

Safety considerations

Potential for off-target effects due to the involvement of PCNA in essential cellular processes.Development of resistance mechanisms.

Biomarkers

PCNA expression level as a marker of cell proliferation

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