Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) mRNA (PELP1 mRNA)

Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) mRNA is the transcript encoding the PELP1 protein, a critical scaffold and coregulator for various nuclear receptors, including the estrogen and androgen receptors. PELP1 plays a pivotal role in both genomic and non-genomic signaling pathways, facilitating the crosstalk between nuclear receptors and growth factor signaling (Source: UniProt Q8IZL8). In many hormonal cancers, PELP1 is significantly overexpressed, driving tumor progression, metastasis, and resistance to endocrine therapies (Source: PubMed PMID: 25103495). Targeting PELP1 mRNA via RNA interference (RNAi) or antisense technologies aims to reduce the levels of the PELP1 protein, thereby inhibiting its oncogenic functions (Source: PubMed PMID: 30154018). This approach is particularly relevant in cases where traditional small-molecule inhibition of the protein is challenging due to its lack of enzymatic activity. Research has demonstrated that knocking down PELP1 mRNA can sensitize cancer cells to existing treatments and suppress tumor growth in preclinical models (Source: PubMed PMID: 21844185). This target represents a promising avenue for precision medicine in hormone-driven malignancies where PELP1 levels are elevated.

Other names

MNAR mRNAModulator of non-genomic activity of estrogen receptor mRNAProline-, glutamic acid- and leucine-rich protein 1 transcript

RNA interference (RNAi) or antisense-mediated degradation of the PELP1 transcript to prevent protein translation