Proline and glutamate rich with coiled coil domain protein 1 (PERCC1)

**Proline and glutamate rich with coiled coil domain protein 1 (PERCC1)** is a transcriptional co-regulator and a newly recognized member of the YAP/TAZ/FAM181 family, containing conserved TEAD-interacting motifs[1]. It is expressed at very low levels in a limited range of tissues, with highest expression in enteroendocrine cells, especially **gastric G cells** and duodenal enteroendocrine cells. PERCC1 plays a critical developmental role in the gastrointestinal tract by promoting the generation and function of enteroendocrine cells required for normal digestive physiology[1][3][4]. Loss of function causes a congenital diarrheal syndrome in humans and mice, due to failure of specific populations of gut endocrine cells to develop, resulting in nutrient malabsorption and failure to thrive[2]. Its precise molecular mechanism involves interaction with TEAD transcription factors—similar to YAP and TAZ—but unlike these canonical targets, PERCC1 currently has no known established interaction with small-molecule drugs and is not a validated therapeutic target[1][2][3][4]. No evidence currently supports a role in adult disease or cancer, and it does not have known drug interactions, biomarker roles, or safety concerns relevant to pharmacology at this time. It is not conventionally considered a therapeutic target, but is of research interest for rare congenital diarrheal diseases[1][2][3][4].

Other names

PERCC1Protein PERCC1Proline and glutamate-rich protein with a coiled coil domainDIAR11ICRgs104protein LOC105371045