Proline rich 14-like protein (PRR14L)

Proline rich 14-like protein (PRR14L) is a large, evolutionarily conserved protein that contains a C-terminal Tantalus domain, which includes a protein phosphatase 2A (PP2A) binding motif, and shares this domain with its paralog PRR14[1][5]. PRR14L localizes to the midbody during cell division and is thought to act as a scaffold for PP2A, influencing cell division and hematopoietic differentiation[5]. PRR14L mutations are associated with certain myeloid neoplasms and age-related clonal hematopoiesis, with functional studies suggesting tumor suppressor-like activity whereby loss leads to increased monocytes and decreased granulocytes[5]. Unlike PRR14, PRR14L is not involved in nuclear lamina/heterochromatin tethering or chromatin organization, and its full spectrum of biological functions is still under investigation[1][5]. Currently, it is not considered a therapeutic target, no interacting drugs have been identified, and no biomarker or safety data exists regarding therapeutic modulation of PRR14L.

Other names

C22orf30MGC50372Proline rich 14-like proteinPRR14Lprotein PRR14Lproline rich 14 like