Proline-rich basic protein 1 (PROB1)

Proline-rich basic protein 1 (PROB1) is an intracellular protein encoded by the PROB1 gene on human chromosome 5q31.2[1]. It is comprised of 1015 amino acids with two distinct proline-rich regions and a domain of unknown function (DUF)[1]. The secondary structure is predicted to be mainly random coil due to the prevalence of proline residues, with some alpha helices and beta sheets[1]. PROB1 does not contain transmembrane domains and is localized to the nucleoplasm, particularly in cardiac and skeletal muscle tissue, where measurable protein is most abundant[1][7]. While ubiquitous mRNA expression is noted across many tissues, its protein expression appears more tissue-selective[1][3][7].\n\nA variety of post-translational modifications are predicted (e.g., S-palmitoylation, O-GlcNAcylation, phosphorylation)[1]. There are no known functional protein interaction partners, although coexpression with SPATA24 and JADE2 has been observed[1]. Currently, no drugs target PROB1, and its functional and clinical significance remain understudied. However, genetic variants have been linked to keratoconus, as well as altered expression in certain cancers and inflammatory states[1][7]. PROB1 lacks known paralogs in humans but has orthologs across mammals[1].\n\nOverall, PROB1 is a proline-rich, intracellular protein with unclear physiological roles and limited disease association evidence; it is not a validated drug target, nor does it fit into established molecular families such as receptors or enzymes[1][7].

Other names

PROB1C5orf65Proline-rich basic protein 1Proline rich basic protein 1Weakly similar to basic proline-rich protein

None known; no mechanisms established for drugs targeting this protein