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Target intelligence / Profile preview
Proline-rich nuclear receptor coactivator 2 (PNRC2)
- Target
- PNRC2
- Molecular classification
- Other, Nuclear receptor coactivator
01
Overview
Proline-rich nuclear receptor coactivator 2 (PNRC2) is a small (~16 kDa) member of the PNRC coactivator family and encodes a 139-amino-acid protein. PNRC2 interacts directly with nuclear receptors through a proline-rich sequence and an SH3 domain-binding motif, functioning as a coactivator for several orphan and classical nuclear receptors in a ligand-dependent or independent fashion. It participates in the control of mRNA stability and decay (notably nonsense-mediated decay), mediating interactions between the decapping complex and nuclear receptor machinery, and may play a role in the regulation of energy balance and hormone biosynthesis in breast tissue. Unlike other coactivators, PNRC2 is distinct in its sequence motifs and molecular interactions.
- Other names
- PNRC2HSPC208Proline-rich nuclear receptor coactivator 2
02
Mechanism of action
Not applicable
03
Biological functions
Nuclear receptor coactivationmRNA catabolic processNonsense-mediated decay (NMD)Recruitment of mRNA decapping machineryInteraction with glucocorticoid receptor-mediated mRNA degradation
04
Disease associations
Cancer (differential expression observed in breast cancer cell lines; role in hormone metabolism regulation)Potential involvement in neurologic and developmental disorders (e.g., Murray Valley Encephalitis, Holoprosencephaly 3)
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