Proline-rich protein 11 (PRR11)

Proline-rich protein 11 (PRR11) is a nuclear, proline-rich protein containing two proline-rich domains and a zinc finger DNA-binding motif, encoded at chromosome 17q22-23. PRR11 functions as a regulator of cell cycle progression, proliferation, migration, invasion, apoptosis, and autophagy. It is upregulated in diverse human cancers, promoting oncogenesis primarily through transcriptional and post-transcriptional effects on targets such as PTTG1 and by interacting with pathways including PI3K/AKT, Wnt/β-catenin, and E2F1. Overexpression of PRR11 is associated with poor prognosis and therapy resistance in several solid tumors, particularly breast, lung, ovarian, gastric, and colorectal cancers. PRR11 is increasingly recognized as an oncogenic driver, prognostic biomarker, and candidate therapeutic target, though no direct clinical inhibitors have been approved or reported as of the current literature.

Other names

Proline-rich protein 11PRR11FLJ11029transcription repressor of MHCII

Drugs targeting downstream or associated pathways (PI3K/AKT/mTOR, Wnt/β-catenin) may indirectly affect PRR11-positive cancer cell growth. Experimental gene silencing (e.g., siRNA knockdown) of PRR11 reduces proliferation and induces apoptosis in cancer cells.