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Proline-rich protein 23B (PRR23B) is a predicted protein in humans, encoded by the PRR23B gene. It belongs to the proline-rich protein family and contains a high proportion of proline residues, but its molecular and cellular function is uncharacterized. There is no evidence supporting its role as a receptor, enzyme, transporter, or established therapeutic target[2][3][4][6][7][8]. PRR23B's best-known features are sequence similarity to other proline-rich proteins like PRR23A and PRR23C, and predicted capacity for protein binding, but there are no convincing reports linking it to signaling, regulation, or disease causality[4][6][7]. Databases and prediction tools assign it to the "other" or "unknown function" category, and it is not implicated in any drug mechanism, disease biomarker panel, or safety concern[4][6][7][8]. The protein is 265 amino acids long, has a predicted molecular weight of ~28.3 kDa[3], and is evolutionarily conserved, but its biological relevance remains unclear. PRR23B is not a validated receptor, enzyme, or established drug target, and available sources do not link it to recognized disease pathways, actionable biology, or drug binding. It is commonly listed in genomic and protein databases for completeness, but its function remains unknown and it does not meet criteria for a therapeutic target, thus the entry is considered "incorrect" for the purposes of drug target curation[6][7][8].
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