Proline-rich protein 5 (PRR5)

Proline-rich protein 5 (PRR5) is a regulatory protein encoded by the PRR5 gene, located on chromosome 22. It comprises a proline-rich domain and serves as an associated subunit of the mTORC2 (mammalian target of rapamycin complex 2), which is a key regulator of cell growth, survival, and cytoskeleton organization in response to growth factor signaling. PRR5 is involved in controlling platelet-derived growth factor receptor beta (PDGFRB) expression and signaling pathways that include Akt and S6K1. Emerging evidence suggests it may act as a tumor suppressor, especially in breast cancer, and is implicated in disease roles ranging from cancer to epilepsy. The function of PRR5 within mTORC2 makes it relevant to therapeutic strategies targeting this signaling axis, although no drugs currently directly target PRR5 in isolation[1][3][6].

Other names

Proline-rich protein 5PRR5PROTOR1PP610Protor-1FLJ20185kProtein observed with Rictor-1PROTOR-1proline-rich protein 5Protor-1.

Inhibition or modulation of mTORC2 signaling pathway (by targeting mTORC2 components, inhibitors may indirectly affect PRR5 function)