Proline-rich protein 7, synaptic (PRR7)

Proline-rich protein 7, synaptic (PRR7) is a transmembrane adaptor protein predominantly expressed in neurons and activated T cells[1][3][4][6]. In neurons, PRR7 localizes to the postsynaptic density and participates in synaptic modulation, particularly by inducing activity-dependent removal of excitatory synapses via exosomal secretion and inhibition of Wnt signaling[2]. PRR7 also serves as a synapse-to-nucleus signaling messenger, modulating NMDA receptor-mediated gene expression and neuronal survival in a c-Jun-dependent manner; its activity links synaptic activity to apoptosis, contributing to excitotoxic neuronal death relevant to neurodegenerative diseases[3][4][6]. In the immune system, PRR7 modulates T cell receptor signaling and apoptosis, fine-tuning immune activation and survival responses[3]. Despite its clear roles in neuronal and T-cell biology, there are currently no known marketed drugs or targeted therapeutics acting directly on PRR7, nor well-characterized use as a disease biomarker or safety concern beyond those related to apoptosis and neurotoxicity[2][3][4][5][6].

Other names

Proline-rich protein 7PRR7MGC10772Synaptic proline-rich membrane proteinProline rich 7 (synaptic)