Proline-rich transmembrane protein 1 (PRRT1)

Proline-rich transmembrane protein 1 (PRRT1) is a membrane protein primarily expressed in the brain, associated with the regulation of AMPA-type glutamate receptors (AMPARs) at extrasynaptic sites. PRRT1 is a component of native AMPAR complexes and is required for maintaining a pool of extrasynaptic AMPARs, thereby playing a critical role in synaptic plasticity such as long-term potentiation and depression. Knockout of PRRT1 in animal models leads to altered surface expression and phosphorylation of AMPARs, as well as impaired synaptic plasticity. PRRT1 is a member of the SynDIG protein family (specifically SynDIG4) and is also classified within the larger Dispanin protein family. It is involved in protein-protein interactions, especially with AMPAR subunits GluA1-GluA4 and the phosphatase PP2B, influencing the trafficking and stabilization of AMPARs during neuronal activity and memory processes[1][3][4][7]. No direct evidence currently implicates PRRT1 as a validated therapeutic target or indicates drug interactions, biomarker roles, or therapeutic safety concerns.

Other names

C6orf31NG5DSPD1SynDIG4IFITMD7Dispanin subfamily D member 1Synapse differentiation-induced protein 4interferon induced transmembrane protein domain containing 7