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Proline-rich transmembrane protein 3 (PRRT3)
- Target
- PRRT3
- Molecular classification
- Transmembrane protein, Proline-rich protein
01
Overview
Proline-rich transmembrane protein 3 (PRRT3) is a protein-coding gene in humans, with the encoded protein predicted to be embedded within the cellular membrane. Its structure includes multiple repeats of short proline-rich sequences, a feature typical within the proline-rich protein family. PRRT3 is implicated in rare inherited conditions such as episodic kinesigenic dyskinesia 1 and Wiedemann-Rautenstrauch syndrome. It is primarily classified as a structural protein, possibly involved in membrane or extracellular matrix organization, but its detailed biological function remains unclear and it has not been established as a druggable target for therapeutic intervention.
- Other names
- PRRT3Proline-rich transmembrane protein 3UNQ5823/PRO19642FLJ33674GC03M009963 (GeneCards ID)HGNC:26591NCBI Gene:285368Ensembl:ENSG00000163704OMIM:619993UniProt:Q5FWE3
02
Mechanism of action
Not applicable; no characterized mechanism due to lack of pharmacological targeting
03
Biological functions
Component of extracellular matrix structural proteinPredicted membrane localization
04
Disease associations
Episodic kinesigenic dyskinesia 1Wiedemann-Rautenstrauch syndrome
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