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Target intelligence / Profile preview
Proline-rich Tyrosine Kinase 2 (PYK2)
- Target
- PYK2
- Molecular classification
- Non-receptor tyrosine kinase, Focal Adhesion Kinase subfamily, Enzyme
01
Overview
Proline-rich tyrosine kinase 2 (PYK2) is a non-receptor tyrosine kinase belonging to the focal adhesion kinase (FAK) subfamily. It is activated by increases in intracellular calcium concentration and plays a role in various cellular processes including synaptic plasticity, immune cell function, bone formation, platelet activation, and cancer progression. PYK2 is considered a therapeutic target for osteoporosis, cancer, and thrombosis.
- Other names
- PTK2BProtein tyrosine kinase 2 betaCell adhesion kinase β
02
Mechanism of action
Inhibition of PYK2 kinase activity
03
Biological functions
Synaptic plasticity regulationImmune cell migrationImmune cell signalingNegative regulation of bone formationCell proliferationCell migrationCell invasionPlatelet activation
04
Disease associations
OsteoporosisCancerInflammationThrombosis
05
Safety considerations
Potential off-target effects due to kinase family homologyEffects on other calcium-dependent signaling pathways
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