Prolyl 3-hydroxylase 2 (P3H2)

Prolyl 3-hydroxylase 2 (P3H2) is an **enzyme** in the Fe(II)- and 2-oxoglutarate–dependent dioxygenase family that catalyzes the formation of 3-hydroxyproline on collagen, notably type IV collagen[1][3]. This post-translational modification is essential for proper collagen assembly, stability, and supramolecular organization. P3H2 is expressed in various connective tissues, including bone and cartilage, as well as in endothelial cells (where its expression is upregulated by VEGF-A)[1][3]. Recent studies demonstrate that P3H2 activity is required for endothelial cell angiogenesis both in vitro and in vivo, identifying it as a potential therapeutic target for diseases involving pathological neovascularization (such as age-related macular degeneration)[1]. Altered P3H2 expression or function has been implicated in certain cancers and connective tissue disorders[3].

Other names

LEPREL1Leprecan-like protein 1Myxoid liposarcoma-associated protein 4Procollagen-proline 3-dioxygenase 2MCVDMLAT4FLJ10718

Enzyme inhibition (potential anti-angiogenic therapy via inhibition of P3H2's collagen hydroxylation activity), modulation of VEGF-A/VEGFR-2 signaling (indirectly through its role in angiogenesis)[1]