Target intelligence / Profile preview

Prolyl Hydroxylase Domain-Containing Protein 1 (PHD1)

Target: PHD1
Molecular classification: Enzyme, 2-oxoglutarate-dependent oxygenase

Overview

Prolyl hydroxylase domain-containing protein 1 (PHD1/EGLN2) is a nuclear-localized enzyme acting primarily as an oxygen sensor that regulates cellular adaptation to varying O₂ levels through post-translational modification—and subsequent proteasomal targeting—of key transcription factors like hypoxia-inducible factor α. It has additional roles influencing gene expression machinery directly and modulating metabolic pathways relevant for disease states such as cancer or ischemic injury.

Other names: EGLN2HPH3

Biological functions

Oxygen sensingRegulation of HIF-αmRNA synthesisCell cycle regulationMetabolic reprogramming

Disease associations

CancerIschemic injury

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