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Prolyl Hydroxylase Domain-Containing Protein 3 (PHD3)
- Target
- PHD3
- Molecular classification
- Enzyme, Dioxygenase, Prolyl Hydroxylase
01
Overview
Prolyl Hydroxylase Domain-Containing Protein 3 (PHD3) is a cellular oxygen sensor and a member of the prolyl hydroxylase family. It regulates the stability of hypoxia-inducible factors (HIFs) by hydroxylating specific proline residues on HIF-alpha subunits, marking them for proteasomal degradation under normoxic conditions. PHD3 has a broader substrate range than other PHD isoforms, impacting cell motility, apoptosis, and other cellular processes. It acts as a tumor suppressor by promoting apoptosis and inhibiting growth, angiogenesis, differentiation, and metastasis. PHD3 expression is induced under hypoxic conditions and its aggregation behavior is oxygen-dependent.
- Other names
- EGLN3Egl-9 family hypoxia inducible factor 3PHIF-PH3HPH-3
02
Mechanism of action
Inhibition of enzymatic activity or modulation of protein-protein interactions.
03
Biological functions
Oxygen sensingHypoxia adaptationMetabolic regulationApoptosisMuscle developmentSympathetic neuronal developmentDNA damage responseRegulation of HIF stability
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to broad substrate range.
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