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Target intelligence / Profile preview
Prolyl Hydroxylase EGLN3 (PHD3)
- Target
- PHD3
- Molecular classification
- Enzyme, Oxidoreductase, Dioxygenase
01
Overview
Prolyl Hydroxylase EGLN3 (PHD3) is an enzyme that functions as an oxygen sensor, primarily regulating cellular responses to hypoxia by hydroxylating proline residues in HIF-alpha subunits. This hydroxylation leads to HIF-alpha degradation under normal oxygen conditions and stabilization under hypoxic conditions. It is also involved in apoptosis regulation and DNA damage response. EGLN3 has clinical relevance as a biomarker and potential therapeutic target in various cancers.
- Other names
- Egl nine homolog 3HPH-1HIF-PH3
02
Mechanism of action
Inhibition of prolyl hydroxylation leading to HIF-alpha stabilization and subsequent gene activation. Modulation of apoptosis pathways.
03
Biological functions
Response to hypoxiaProtein hydroxylationRegulation of cysteine-type endopeptidase activity involved in apoptotic processesCellular responses to stimuliRegulation via proteasome-mediated degradation pathwaysOxygen sensing
04
Disease associations
Renal cell carcinomaPolycythemiaCancer (general, gastric cancer specifically)
05
Biomarkers
Clear cell renal cell carcinomaPrognostic marker for gastric cancer
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