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Prolyl Oligopeptidase
- Molecular classification
- Enzyme, Serine protease, Serine endopeptidase
01
Overview
Prolyl oligopeptidase (POP), also known as prolyl endopeptidase, is a serine endopeptidase that specifically cleaves peptide bonds at the carboxyl side of internal proline residues in oligopeptides shorter than about 30 amino acids. It is involved in neuropeptide metabolism and has been implicated in various neurological and psychiatric disorders. It is encoded by the PREP gene.
- Other names
- Prolyl endopeptidase (PE)Post-proline cleaving enzyme
02
Mechanism of action
Inhibition of prolyl oligopeptidase activity
03
Biological functions
Neuropeptide metabolismSignal transductionCell proliferationCell differentiationRegulation of inositol 1,4,5-triphosphate signalingProtein-protein interactions
04
Disease associations
Cognitive declineDementiaNeurodegenerative diseaseParkinson’s diseaseAlzheimer’s diseasePsychiatric disorderAutism spectrum disorderSchizophreniaManiaDepressionCeliac disease
05
Safety considerations
Incomplete understanding of physiological rolesLimited clinical translation due to distribution patterns
06
Interacting drugs
POP inhibitors
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