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Prolyl-tRNA synthetase

Molecular classification: Enzyme, Aminoacyl-tRNA synthetase, Class IIa aminoacyl-tRNA synthetase

Overview

Prolyl-tRNA synthetase (ProRS) is an essential enzyme in protein synthesis, responsible for catalyzing the attachment of the amino acid proline to its corresponding tRNA (tRNA^Pro). This process, known as aminoacylation or "charging," is critical for accurate translation. It is a validated drug target against parasites such as Plasmodium spp., Toxoplasma gondii, Cryptosporidium spp.

Other names: ProRSPROS

Mechanism of action

Competitive binding at the active site alongside ATP/proline substrates, inhibiting tRNA aminoacylation

Biological functions

Protein biosynthesistRNA aminoacylationTranslation fidelity

Disease associations

Infection

Interacting drugs

Halofuginone

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