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Proopiomelanocortin pathway (POMC pathway)
- Target
- POMC pathway
- Molecular classification
- Other (peptide precursor pathway)
01
Overview
The Proopiomelanocortin pathway is a biological pathway centered around the precursor protein proopiomelanocortin (POMC). POMC is processed into several peptides, including adrenocorticotropic hormone (ACTH), melanocyte-stimulating hormones (α-, β-, and γ-MSH), and β-endorphin. These peptides play critical roles in regulating stress response, energy balance, skin pigmentation, and pain relief. The pathway is crucial for maintaining glucose homeostasis and body weight, and it serves as a therapeutic target for obesity and related metabolic disorders.
- Other names
- Proopiomelanocortin systemMelanocortin pathway
02
Mechanism of action
Regulation of melanocortin receptors to influence energy balance and hormone secretion
03
Biological functions
Signal transductionEnergy metabolismHormone regulationImmune responseGlucose homeostasis
04
Disease associations
ObesityInflammationAdrenal insufficiencyHyperpigmentationType 2 diabetes
05
Safety considerations
Adverse effects of drugs targeting this pathway may include changes in appetite, energy expenditure, or cortisol levels
06
Interacting drugs
Setmelanotide
3 more in the full profile.
07
Biomarkers
ACTHα-MSHβ-endorphinleptin
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