Target intelligence / Profile preview

Propionyl-coenzyme A (Propionyl-CoA)

Target: Propionyl-CoA
Molecular classification: Aceticoids, Acetyl coenzymes, Acyl CoAs

Overview

Propionyl-CoA is a key intermediate in the metabolism of odd-chain fatty acids and certain amino acids (methionine, valine, isoleucine, threonine). It is converted to methylmalonyl-CoA by propionyl-CoA carboxylase (PCC), then to succinyl-CoA by methylmalonyl CoA mutase, allowing entry into the citric acid cycle. Deficiency in PCC leads to propionic aciduria.

Other names: propanoyl-coenzyme AS-propanoyl-CoA

Biological functions

Metabolic intermediate in fatty acid catabolismMetabolic intermediate in amino acid catabolismPrecursor for TCA cycle entry

Disease associations

Propionic aciduriaOrganic acidemias

Safety considerations

Accumulation leads to toxic levels of propionic acid derivatives.Secondary carnitine deficiency

Beyond the preview

Go deeper on Propionyl-coenzyme A (Propionyl-CoA).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Propionyl-coenzyme A (Propionyl-CoA).

Explore the full profile