Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Prosaposin-Progranulin Complex (PSAP-PGRN Complex)
- Target
- PSAP-PGRN Complex
- Molecular classification
- Protein Complex
01
Overview
The prosaposin-progranulin complex is a molecular assembly formed by the physical interaction between prosaposin (PSAP) and progranulin (PGRN). This interaction is crucial for the delivery of each protein to the lysosome and has significant implications in neurodegenerative diseases. PSAP facilitates PGRN’s targeting to lysosomes. Both proteins are critical for maintaining normal degradative activity within lysosomes. Mutations or deficiencies affecting either component disrupt trafficking/function leading to accumulation of undegraded substrates—a hallmark in FTLD or NCL pathology. Stabilizing this complex pharmacologically may offer therapeutic benefits against neurodegeneration.
02
Mechanism of action
Augmenting or stabilizing the prosaposin-progranulin complex to enhance progranulin’s half-life/functionality in brain tissue
03
Biological functions
Lysosomal TraffickingLysosomal HomeostasisNeuroprotectionProtein DegradationSphingolipid MetabolismNeurotrophic Signaling
04
Disease associations
Frontotemporal Lobar DegenerationNeuronal Ceroid LipofuscinosisNeurodegenerative Disease
05
Safety considerations
Potential for off-target effects due to complex nature of interactionLong-term effects of modulating lysosomal function require careful consideration
06
Interacting drugs
AZP2006
Beyond the preview
Go deeper on Prosaposin-Progranulin Complex (PSAP-PGRN Complex).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Prosaposin-Progranulin Complex (PSAP-PGRN Complex).