Prospero homeobox protein 2 (PROX2)

Prospero homeobox protein 2 (PROX2) is a DNA-binding transcription factor and member of the homeobox protein family, predicted to regulate transcription by RNA polymerase II in a sequence-specific manner[2][7]. It is a paralog of PROX1 and is involved in developmental processes as a cell fate determinant[1][2]. In model organisms, loss of PROX2 appears dispensable for embryonic development and postnatal survival, with expression reported in postnatal eye, adult testes, and embryos, but no clear essential or disease-driving functions in humans have been confirmed[1][2][7]. Disease associations are limited, primarily reported with atrial septal defect[2], and there are currently no known drugs, biomarkers, or established therapeutic targeting of PROX2.

Other names

Prospero homeobox 2PROX-2FLJ36749Homeobox prospero-like protein PROX2prospero homeobox protein 2homeobox prospero-like protein PROX2