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Prostacyclin Receptor (IP)
- Target
- IP
- Molecular classification
- G protein-coupled receptor, GPCR, Rhodopsin-like Class A GPCR, Receptor
01
Overview
The prostacyclin receptor (IP), encoded by the PTGIR gene, is a G protein-coupled receptor that binds prostacyclin (prostaglandin I2 or PGI2). Activation of the IP receptor leads to vasodilation, inhibition of platelet aggregation, and moderation of vascular smooth muscle cell function, contributing to cardioprotection. It is a therapeutic target for pulmonary arterial hypertension and other diseases involving vasoconstriction or thrombosis. Dysfunction or reduced signaling can increase cardiovascular risk.
- Other names
- Prostaglandin I2 receptorPTGIR
02
Mechanism of action
Agonists bind to the IP receptor, activating Gs proteins, stimulating adenylate cyclase, increasing intracellular cAMP levels, and leading to downstream effects mediated by PKA and Epac.
03
Biological functions
Signal transductionVasodilationInhibition of platelet aggregationModeration of proliferation, migration, and differentiation of vascular smooth muscle cells
04
Disease associations
Pulmonary arterial hypertensionCardiovascular diseaseAtherothrombosis
05
Safety considerations
HypotensionBleeding riskSide effects associated with prostacyclin analogs
06
Interacting drugs
Prostacyclin analogs (e.g., treprostinil, iloprost, selexipag)
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