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Target intelligence / Profile preview
Prostaglandin D₂ receptor 2 (CRTH2)
- Target
- CRTH2
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
Prostaglandin D₂ receptor 2 (CRTH2), also known as DP2, is a G protein-coupled receptor that binds prostaglandin D₂ (PGD₂). It is highly expressed on Th2 lymphocytes, eosinophils, and basophils and mediates their chemotaxis and activation. CRTH2 plays a central role in allergic inflammation and is a therapeutic target for allergic diseases like asthma and atopic dermatitis. Activation of CRTH2 leads to decreased cAMP levels, increased intracellular calcium, and activation of the PI3K-AKT-GSK/NFAT axis.
- Other names
- DP2GPR44CD294PTGDR2
02
Mechanism of action
CRTH2 antagonism; blocking the binding of PGD₂ to CRTH2, inhibiting downstream signaling and cellular recruitment.
03
Biological functions
ChemotaxisRecruitment of Th2 lymphocytes, eosinophils, basophilsT-cell polarizationSignal transductionInflammatory response
04
Disease associations
Allergic diseasesAsthmaAtopic dermatitisCrohn's diseaseColitisInflammation
05
Interacting drugs
Fevipiprant
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