Prostaglandin D receptor 1 (DP1)

Prostaglandin D receptor 1 (PTGDR1), also known as DP1, is a G protein-coupled receptor that binds prostaglandin D2 (PGD2). It is primarily expressed on immune cells, airway epithelial cells, vascular endothelium, and certain brain regions. DP1 mediates vasodilation, inhibits platelet aggregation, modulates allergic inflammation, and plays a role in cough reflex and reproductive development. Its association with asthma makes it a target of interest for respiratory disease research.

Other names

PTGDRPTGDR1DPAS1ASTR1

Activation of adenylate cyclase via Gαs subunit, leading to increased intracellular cAMP levels and subsequent activation of protein kinase A (PKA) or PKA-independent signaling.