Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Prostaglandin D Receptor 2 (CRTH2)
- Target
- CRTH2
- Molecular classification
- G protein-coupled receptor, GPCR
01
Overview
Prostaglandin D Receptor 2 (CRTH2), also known as DP2, is a G protein-coupled receptor that binds prostaglandin D2 (PGD2). It is highly expressed on Th2 cells, eosinophils, and basophils, mediating their recruitment and activation during allergic inflammation. Activation of CRTH2 leads to decreased cAMP levels and increased intracellular calcium, promoting chemotaxis and inflammatory responses. It is considered a therapeutic target for allergic diseases like asthma and atopic dermatitis, as well as inflammatory conditions like Crohn's disease and colitis.
- Other names
- DP2GPR44CD294
02
Mechanism of action
Antagonism of CRTH2 receptor, inhibiting PGD2 binding and downstream signaling
03
Biological functions
Signal transductionChemotaxisImmune cell recruitmentInflammation
04
Disease associations
Allergic inflammationAsthmaAtopic dermatitisCrohn's diseaseColitis
Beyond the preview
Go deeper on Prostaglandin D Receptor 2 (CRTH2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Prostaglandin D Receptor 2 (CRTH2).