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Target intelligence / Profile preview
Prostaglandin D2 (PGD2)
- Target
- PGD2
- Molecular classification
- Lipid, Prostanoid, Prostaglandin
01
Overview
Prostaglandin D2 (PGD2) is a bioactive lipid compound belonging to the prostaglandin family, derived from arachidonic acid. It is primarily produced by mast cells and plays significant roles in inflammation, allergic responses, neuromodulation, and sleep regulation. PGD2 exerts its effects mainly through two G protein-coupled receptors, PTGDR (DP1) and CRTH2 (DP2).
02
Mechanism of action
Inhibition of cyclooxygenases (COX-1, COX-2) leading to decreased PGD2 synthesis.
03
Biological functions
InflammationBronchoconstrictionVasoconstriction/VasodilationInhibition of platelet aggregationNociception regulationSleep inductionNeuromodulationAllergic reactionsPancreatic glucagon secretion stimulationAnti-metastatic activity
04
Disease associations
InflammationAllergic diseases (e.g., asthma)Sleep disorders
05
Safety considerations
Bronchoconstriction in asthmaPotential involvement in allergic responses
06
Interacting drugs
Aspirin
1 more in the full profile.
07
Biomarkers
Urine assays reflecting systemic production/excretion rates
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