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Target intelligence / Profile preview
Prostaglandin D2 Receptor (PTGDR)
- Target
- PTGDR
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The prostaglandin D2 receptor (PTGDR), also known as the DP receptor, is a G protein-coupled receptor activated by prostaglandin D2 (PGD2). There are two main subtypes: DP1/PTGDR1 and DP2/CRTH2/PTGDR2. DP1 primarily couples to Gs proteins, increasing cAMP, while DP2 influences Th2 cell recruitment. These receptors play crucial roles in inflammatory and allergic responses, as well as various physiological processes like sleep regulation and hair growth, making them potential therapeutic targets for conditions such as asthma and alopecia.
- Other names
- DP receptorDP1PTGDR1DP2CRTH2PTGDR2
02
Mechanism of action
Agonist or antagonist binding to PTGDR (DP1 or DP2) modulates downstream signaling pathways, including cAMP production and intracellular calcium levels, thereby affecting various cellular functions.
03
Biological functions
Signal transductionRegulation of sleepBody temperature controlOlfactory functionHormone releasePlatelet aggregation inhibitionVasodilationSmooth muscle relaxationBronchoconstrictionMucosal secretionIncreased vascular permeabilityChemotaxisCytokine/chemokine production modulationImmune response regulationHair growth regulation
04
Disease associations
AsthmaAllergic diseasesAllergic rhinitisAtopic dermatitisAndrogenic alopeciaInflammation
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