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Prostaglandin D2 Synthesis Pathway (PGD2 Synthesis Pathway)
- Target
- PGD2 Synthesis Pathway
- Molecular classification
- Metabolic pathway
01
Overview
The prostaglandin D2 (PGD2) synthesis pathway is a biochemical cascade responsible for the production of PGD2, a bioactive lipid mediator involved in diverse physiological and pathological processes such as inflammation, immune response, sleep regulation, and male sexual development. PGD2 is primarily produced by mast cells but is also synthesized in the central nervous system and other tissues. The pathway begins with arachidonic acid, which is converted to PGD2 via cyclooxygenases and prostaglandin D synthases.
02
Mechanism of action
Cyclooxygenase inhibition (upstream regulators)
03
Biological functions
Prostaglandin synthesisInflammation modulationSleep regulationMale sexual developmentImmune response
04
Disease associations
AsthmaAllergyMale pattern baldnessInflammation
05
Interacting drugs
Aspirin
1 more in the full profile.
06
Biomarkers
PGD2 levels as a marker of inflammation/allergy
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