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Target intelligence / Profile preview
Prostaglandin E Receptor (PGE Receptor)
- Target
- PGE Receptor
- Molecular classification
- G protein-coupled receptor
01
Overview
The prostaglandin E receptor refers to a family of G protein-coupled receptors (GPCRs) that mediate the effects of prostaglandin E2 (PGE2), a key lipid mediator involved in numerous physiological and pathological processes. There are four main subtypes of this receptor, known as EP1, EP2, EP3, and EP4. Each subtype is encoded by a distinct gene (PTGER1–4) and exhibits unique tissue distribution, signaling mechanisms, and biological functions.
- Other names
- PGE receptorProstanoid EP receptorPGE₂R
02
Mechanism of action
Agonist or antagonist for EP1, EP2, EP3 and EP4 receptors
03
Biological functions
Signal transductionSmooth muscle contractionSmooth muscle relaxationPain perceptionFever responseGastric mucosal protectionRegulation of motilityWater/ion transportVascular tone regulationImmune modulationCytokine productionVascular permeabilityAllergy responsesCell proliferationCell survival
04
Disease associations
PainFeverHypertensionAllergic reactionsGastrointestinal ulcersCancerInflammation
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