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Prostaglandin E Receptor 1 (None)
- Target
- None
- Molecular classification
- G protein-coupled receptor, GPCR, Rhodopsin-like GPCRs, Subfamily A14, Receptor
01
Overview
Prostaglandin E receptor 1 (EP1) is a G protein-coupled receptor that primarily binds prostaglandin E2 (PGE2). Upon activation by PGE2, it stimulates the phosphatidylinositol-calcium second messenger system, leading to increased intracellular calcium levels and subsequent cellular responses. It plays critical roles in pain perception, blood pressure regulation, renal function, and smooth muscle contraction. Targeting the EP1 receptor has been explored for managing conditions such as pain, hypertension, preterm labor, and certain cancers.
- Other names
- EP1 receptorPTGER1
02
Mechanism of action
Gq protein activation; stimulation of phosphatidylinositol-calcium second messenger system; increased intracellular calcium levels
03
Biological functions
Signal transductionPain perceptionBlood pressure regulationRenal modulationSmooth muscle contractionKeratinocyte differentiation
04
Disease associations
PainHypertensionPreterm laborCancerNon-melanoma skin cancer
05
Safety considerations
Interspecies differences between animal models and humans complicate direct translation of findings.Potential for cardiovascular side effects due to blood pressure regulation.
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