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Target intelligence / Profile preview
Prostaglandin E Receptor 2 (EP2)
- Target
- EP2
- Molecular classification
- G protein-coupled receptor, GPCR, Rhodopsin-like GPCRs, Subfamily A14
01
Overview
Prostaglandin E receptor 2 (EP2) is a G protein-coupled receptor that binds prostaglandin E2 (PGE2), a bioactive lipid involved in numerous physiological and pathological processes. Upon activation by PGE2, EP2 couples to Gs proteins, leading to increased intracellular cAMP and activation of protein kinase A (PKA). It is widely expressed and mediates diverse biological effects, including modulation of inflammation, regulation of immune cell function, vasodilation, and smooth muscle relaxation. EP2 has been implicated as an important mediator or therapeutic target for cancer, cardiovascular disease, fibrosis, and wound healing.
- Other names
- Prostaglandin E receptor 2PTGER2
02
Mechanism of action
Gs protein activation, increased cAMP production, PKA activation
03
Biological functions
Signal transductionInflammation modulationVasodilationSmooth muscle relaxationImmune regulationHematopoietic stem cell homeostasisTissue repairWound healing
04
Disease associations
CancerCardiovascular diseaseFibrosisInflammatory diseases
05
Safety considerations
Context-dependent pro-inflammatory and anti-inflammatory actionsPotential for off-target effects due to widespread expression
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