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Target intelligence / Profile preview
Prostaglandin E receptor 3 (EP3)
- Target
- EP3
- Molecular classification
- G protein-coupled receptor
01
Overview
Prostaglandin E receptor 3 (EP3) is a G protein-coupled receptor that mediates cellular responses to prostaglandin E2 (PGE2). It is involved in various physiological and pathological processes, including the regulation of insulin secretion, modulation of noradrenaline release, and platelet aggregation. There are multiple isoforms of EP3 generated by alternative splicing, which vary in their tissue expression and signaling pathways. EP3 has been implicated in diabetes, cancer, and cardiovascular functions.
- Other names
- PTGER3
02
Mechanism of action
Mediates cellular responses to prostaglandin E2 (PGE2) via Gi, Gq, and Gs protein signaling pathways.
03
Biological functions
Signal transductionRegulation of insulin secretionModulation of noradrenaline releasePlatelet aggregation
04
Disease associations
DiabetesCancerCardiovascular disease
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