Prostaglandin E synthase 2 (PTGES2)

Prostaglandin E synthase 2 (PTGES2) is a membrane-associated enzyme in the GST superfamily responsible for converting prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2) in the prostaglandin synthesis pathway. PTGES2 is constitutively expressed in various tissues and cell types, including striated muscle, neurons, hepatocytes, astrocytes, and endothelium, typically localized to the Golgi apparatus and mitochondria[1][3][5]. Unlike closely related enzymes, it is not glutathione-dependent. PTGES2 is thought to participate in inflammatory processes, as PGE2 is a key mediator of inflammation; however, PTGES2 itself is not induced by inflammatory stimuli and is generally constitutively expressed[1][8]. PTGES2 may also modulate transcription in response to interferon-gamma signaling[3]. It is considered a potential drug target for anti-inflammatory therapies, and its inhibition may reduce PGE2-mediated disease processes, but with associated risks due to disruption of homeostatic prostaglandin functions[3][8].

Other names

C9orf15GBF-1mPGES2Microsomal prostaglandin E synthase-2

Inhibition of PTGES2 reduces production of prostaglandin E2, thereby modulating inflammation and pain; drugs may act by binding and inhibiting enzyme activity