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Target intelligence / Profile preview
Prostaglandin E1 (PGE1)
- Target
- PGE1
- Molecular classification
- Prostaglandin, Lipid mediator
01
Overview
Prostaglandin E1 (PGE1), also known as alprostadil, is a naturally occurring prostaglandin that acts as a potent vasodilator and smooth muscle relaxant. It is used to maintain the patency of the ductus arteriosus in neonates with congenital heart defects and to treat erectile dysfunction.
- Other names
- Alprostadil(13E,15S)-11α,15-dihydroxy-9-oxoprost-13-en-1-oic acid
02
Mechanism of action
PGE1 exerts its effects primarily through binding to specific G protein-coupled receptors known as EP receptors—subtypes EP1, EP2, EP3, and EP4. This binding leads to vasodilation, inhibition of platelet aggregation, and relaxation of smooth muscle tissue.
03
Biological functions
VasodilationSmooth muscle relaxationInhibition of platelet aggregationInflammatory response modulation
04
Disease associations
Erectile dysfunctionCongenital heart defectsPeripheral arterial occlusive disease
05
Safety considerations
Apnea (neonates)Hypotension (neonates)Fever (neonates)Penile painPriapismBleeding at injection site
06
Interacting drugs
Alprostadil
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