Target intelligence / Profile preview

Prostaglandin E2 EP2 Receptor (EP2)

Target: EP2
Molecular classification: G protein-coupled receptor, Receptor

Overview

The Prostaglandin E2 EP2 receptor (EP2) is a G protein-coupled receptor (GPCR) that binds prostaglandin E2 (PGE₂), a lipid mediator involved in numerous physiological and pathological processes. It primarily couples to Gs proteins, leading to increased cAMP levels and PKA activation. EP2 mediates diverse biological effects, including smooth muscle relaxation, immune modulation, and neuroprotection. It is implicated in cancer progression and is considered a potential drug target for both agonists and antagonists.

Other names: PTGER2

Mechanism of action

Gs protein activation, increased cAMP levels, PKA activation

Biological functions

Signal transductionSmooth muscle relaxationImmune modulationNeurotransmissionCell proliferation

Disease associations

InflammationCancerNeurodegenerative disease

Safety considerations

Context-dependent effects; both inhibition and stimulation may have therapeutic value depending on the disease state.

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