Prostaglandin E2 Receptor (PGE2 receptor)

The prostaglandin E2 receptor (PGE2 receptor) refers to a family of G protein-coupled receptors (GPCRs) that bind and are activated by prostaglandin E2, a key lipid mediator involved in numerous physiological and pathological processes. There are four main subtypes of PGE2 receptors, known as EP1, EP2, EP3, and EP4. Each subtype is encoded by a distinct gene and exhibits unique tissue distribution, signaling mechanisms, and biological functions. Targeting specific PGE² receptor subtypes offers potential for treating various conditions, including inflammatory diseases, cancer, and neurological disorders. Selective antagonists or agonists for these receptors are under investigation as next-generation anti-inflammatory or antiproliferative agents.

Other names

Prostaglandin E2 receptorsEP1 receptorEP2 receptorEP3 receptorEP4 receptorPTGER1PTGER2PTGER3PTGER4Prostaglandin E2 receptor 1Prostaglandin E2 receptor 2Prostaglandin E2 receptor 3Prostaglandin E2 receptor 4

G protein-coupled receptor signaling modulation