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Target intelligence / Profile preview
Prostaglandin E2 Receptor 3 (EP3)
- Target
- EP3
- Molecular classification
- G protein-coupled receptor, GPCR, Rhodopsin-like GPCR, Subfamily A14
01
Overview
The Prostaglandin E2 receptor 3 (EP3) is a G protein-coupled receptor (GPCR) that binds prostaglandin E2 (PGE2), a lipid mediator involved in various physiological and pathological processes. Activation of EP3 leads to diverse effects depending on the tissue context, impacting metabolism, pain modulation, cardiovascular function, and gastrointestinal protection. EP3 is considered a therapeutic target for diseases like obesity, diabetes, inflammatory pain, and heart failure.
- Other names
- PTGER3PGE2 Receptor 3
02
Mechanism of action
Gi protein-mediated inhibition of adenylate cyclase/cAMP; some increase Ca²⁺
03
Biological functions
Signal transductionRegulation of adipogenesisRegulation of insulin secretionPain modulationInflammation modulationCardiovascular functionGastrointestinal mucosal defenseFever responseBlood coagulation
04
Disease associations
ObesityDiabetesInflammatory painMyocardial infarctionHeart failureGastrointestinal ulceration
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