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Target intelligence / Profile preview
Prostaglandin E2 receptor EP2 (EP2)
- Target
- EP2
- Molecular classification
- G protein-coupled receptor (GPCR), Rhodopsin-like GPCR family, Subfamily A14 GPCR
01
Overview
Prostaglandin E2 receptor EP2 (EP2) is a G protein-coupled receptor (GPCR) that binds prostaglandin E2 (PGE2). It is encoded by the PTGER2 gene and is widely distributed throughout the body, mediating diverse biological effects through cAMP signaling and β-arrestin pathways. EP2 is involved in inflammation, cancer, and other pathological processes and is considered a therapeutic target for drug discovery.
- Other names
- PTGER2
02
Mechanism of action
Activation by PGE2 stimulates adenylate cyclase, increasing cAMP levels and activating PKA or Epac pathways. Can also signal through β-arrestin pathways activating JNK or ERK kinases.
03
Biological functions
Immune response modulationSmooth muscle relaxationNeural developmentEndocrine regulationCardiovascular regulationRenal regulationReproductive system regulationSignal transduction
04
Disease associations
InflammationCancerFibrotic diseases
05
Safety considerations
Potential for off-target effects due to broad tissue distributionInhibition may disrupt normal physiological functions
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