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Target intelligence / Profile preview
Prostaglandin E2 Receptor EP4 (EP4)
- Target
- EP4
- Molecular classification
- G protein-coupled receptor
01
Overview
The Prostaglandin E₂ Receptor EP₄ subtype is a widely expressed GPCR that mediates many physiological effects of PGE₂ through cAMP-dependent signaling but also engages additional pathways. Its diverse biological actions make it both an attractive therapeutic target for inflammatory diseases—and a molecule requiring caution due to potential tumor-promoting effects depending on disease setting.
- Other names
- PTGER4
02
Mechanism of action
Agonism or antagonism of EP4 receptor to modulate downstream signaling pathways including cAMP/PKA/CREB, PI3K/AKT/mTOR, ERK/MAPK, and p38 MAPK.
03
Biological functions
Smooth muscle relaxationRenal function regulationIntestinal epithelial transportAldosterone secretion modulationUterine functionBone homeostasisImmune modulationInflammation controlPain perceptionFever response regulationMucosal integrity maintenanceHearing development/functionAngiogenesisCell proliferationCell differentiationCell survivalLipid metabolism
04
Disease associations
Inflammatory diseasesThrombotic disordersVascular diseaseCancer
05
Safety considerations
Potential pro-tumorigenic and pro-angiogenic effectsContext-dependent effects requiring careful consideration
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