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Target intelligence / Profile preview
Prostaglandin E2 Synthesis Pathway (PGE2 Pathway)
- Target
- PGE2 Pathway
- Molecular classification
- Pathway, Metabolic Pathway
01
Overview
The prostaglandin E2 (PGE2) synthesis pathway is a key biochemical cascade responsible for the production of PGE2, a lipid mediator involved in inflammation, immune regulation, and various physiological processes. PGE2 is synthesized from arachidonic acid (AA), which is released from membrane phospholipids upon cellular stimulation or damage. Key enzymes involved include phospholipase A2, cyclooxygenases (COX-1 and COX-2), and prostaglandin E synthases (mPGES-1, mPGES-2, cPGES). PGE2 exerts its effects through EP receptors (EP1-EP4).
02
Mechanism of action
Inhibition of COX enzymes (NSAIDs)
03
Biological functions
Inflammation mediationImmune response modulationVascular tone regulationReproductive process controlAutocrine/paracrine signaling
04
Disease associations
Inflammatory diseasesRheumatoid arthritisOsteoarthritis
05
Safety considerations
Gastrointestinal side effects (NSAIDs)Cardiovascular side effects (NSAIDs)
06
Interacting drugs
NSAIDs
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