Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Prostaglandin-Endoperoxide Synthase (Cyclooxygenase) (COX)
- Target
- COX
- Molecular classification
- Enzyme, Heme peroxidase
01
Overview
Prostaglandin-endoperoxide synthase, commonly known as cyclooxygenase (COX), is a key enzyme responsible for the biosynthesis of prostanoids, including prostaglandins, thromboxanes, and prostacyclins from arachidonic acid. There are two main isoforms: COX-1 (constitutively expressed, involved in homeostatic functions) and COX-2 (inducible, primarily associated with inflammation). Inhibition of COX is the mechanism of action for NSAIDs. COX converts arachidonic acid into PGH2, a precursor for other prostanoids, playing roles in inflammation, vascular tone, thrombosis, and other physiological processes.
- Other names
- Prostaglandin G/H synthaseProstaglandin H2 synthasePGHSCyclooxygenase
02
Mechanism of action
Inhibition of cyclooxygenase activity, preventing the synthesis of prostaglandins, thromboxanes, and prostacyclins.
03
Biological functions
Prostaglandin synthesisThromboxane A2 synthesisProstacyclin synthesisInflammation mediationVascular homeostasisPlatelet functionRegulation of gastric mucosaRegulation of renal blood flow
04
Disease associations
InflammationPainFeverCardiovascular diseaseCancerNeuroinflammationThrombosis
05
Safety considerations
Gastrointestinal side effects (with non-selective NSAIDs)Cardiovascular risks (with some COX-2 inhibitors)
06
Interacting drugs
Aspirin
3 more in the full profile.
Beyond the preview
Go deeper on Prostaglandin-Endoperoxide Synthase (Cyclooxygenase) (COX).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Prostaglandin-Endoperoxide Synthase (Cyclooxygenase) (COX).