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Target intelligence / Profile preview
Prostaglandin F2α (PGF2α)
- Target
- PGF2α
- Molecular classification
- Prostaglandin, Lipid mediator, Eicosanoid
01
Overview
Prostaglandin F2α (PGF2α) is a bioactive lipid molecule belonging to the prostaglandin family. It plays critical roles in reproductive physiology, inflammation, and other processes by acting through its specific FP receptor. It induces luteolysis, stimulates uterine muscle contractions, and increases inflammation in myometrial cells. PGF2α analogues are used clinically to induce labor or abortion, and as active ingredients or templates for drugs treating glaucoma.
- Other names
- PGF2alphaProstaglandin F2 alpha
02
Mechanism of action
Agonist of the FP receptor, leading to activation of phospholipase C (PLC), production of inositol triphosphate (IP3) and diacylglycerol (DAG), mobilization of intracellular calcium, and activation of protein kinase C (PKC).
03
Biological functions
Smooth muscle contractionInflammationLuteolysisUterine contractionVasoconstriction
04
Disease associations
InflammationReproductive disordersGlaucomaCardiovascular disease
05
Safety considerations
Uterine contractionInflammationCardiovascular effects
06
Interacting drugs
PGF2α analogues
3 more in the full profile.
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