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Target intelligence / Profile preview
Prostaglandin F2α Receptor (FP)
- Target
- FP
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The prostaglandin F2α receptor (FP) is a G protein-coupled receptor that binds and mediates the biological actions of prostaglandin F2α (PGF2α). It plays a crucial role in female reproductive function, particularly in luteolysis and uterine contraction. It is also implicated in cardiovascular regulation and related diseases.
- Other names
- PTGFR
02
Mechanism of action
Agonist-induced activation of Gq proteins, leading to PLC activation, IP3 production, and increased intracellular calcium levels. Can also activate G12/G13 and Gi proteins.
03
Biological functions
Signal transductionSmooth muscle contractionLuteolysisBlood pressure regulation
04
Disease associations
Reproductive disordersCardiovascular diseaseHypertensionAtherosclerosis
05
Safety considerations
Uterotonic effectsVasoconstriction
06
Interacting drugs
Prostaglandin F2α
1 more in the full profile.
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