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Target intelligence / Profile preview
Prostaglandin F2 alpha receptor (FP)
- Target
- FP
- Molecular classification
- G protein-coupled receptor
01
Overview
The prostaglandin F2 alpha receptor (FP, gene PTGFR) is a G protein-coupled receptor that binds prostaglandin F2α (PGF2α), a potent lipid mediator involved in various physiological and pathological processes. It plays a central role in female reproduction, cardiovascular function, and other processes. It is targeted by drugs used for inducing labor/abortion and modulating intraocular pressure. Dysregulation is linked with hypertension and cardiovascular disease.
- Other names
- PTGFR
02
Mechanism of action
Primarily couples to Gq proteins activating phospholipase C, increasing IP3/diacylglycerol, and mobilizing intracellular Ca²⁺. Can also activate Rho family GTPases via G12/G13 proteins and in some cells, couples to Gi proteins.
03
Biological functions
LuteolysisParturitionUterine smooth muscle contractionBlood pressure regulationSignal transductionVasoconstriction
04
Disease associations
HypertensionCardiovascular diseaseGlaucoma
05
Safety considerations
Potential for unintended uterine contractionsPotential for cardiovascular effects
06
Interacting drugs
Dinoprost
1 more in the full profile.
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