Target intelligence / Profile preview

Prostaglandin H2 (PGH2)

Target: PGH2
Molecular classification: Eicosanoid, Lipid mediator, Prostaglandin

Overview

Prostaglandin H2 (PGH2) is a key intermediate in the biosynthesis of prostaglandins and thromboxanes. It is synthesized from arachidonic acid by cyclooxygenase (COX) enzymes. PGH2 itself acts primarily as a precursor and activates the thromboxane TP receptor. It is not considered a primary drug target, but rather a crucial intermediate in the eicosanoid pathway that is affected by drugs like NSAIDs. Thus, there is no 'Prostaglandin H2 receptor.'

Mechanism of action

Inhibition of COX enzymes, blocking PGH2 synthesis

Biological functions

Precursor in eicosanoid synthesisVasoconstriction/dilationPlatelet aggregationInflammation (indirectly)Vascular homeostasis (indirectly)Pain perception (indirectly)

Disease associations

InflammationCardiovascular diseasePain

Safety considerations

Gastrointestinal side effects with NSAIDsCardiovascular risks with NSAIDs

Interacting drugs

Aspirin

2 more in the full profile.

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