Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Prostaglandin I2 synthase (PTGIS)
- Target
- PTGIS
- Molecular classification
- Enzyme, Cytochrome P450 isomerase family
01
Overview
Prostaglandin I2 synthase (PTGIS), also known as prostacyclin synthase or CYP8A1, is an enzyme in the cytochrome P450 superfamily that catalyzes the conversion of prostaglandin H2 into prostacyclin (prostaglandin I2). Prostacyclin acts as a potent vasodilator and inhibitor of platelet aggregation. The balance between its production and that of thromboxane A2 plays a critical role in cardiovascular health. Dysregulation can contribute to conditions such as myocardial infarction and stroke. PTGIS is considered an important therapeutic target for cardiovascular diseases and pulmonary arterial hypertension; several drugs act by mimicking or enhancing its product's effects.[4][5][3]
- Other names
- prostacyclin synthaseprostaglandin-I synthasePGI2 synthaseCYP8A1PGISprostacyclin synthetaseprostagladin I2 synthetase
02
Mechanism of action
Agonism at the IP receptor leading to vasodilation and inhibition of platelet aggregation
03
Biological functions
Catalyzes conversion of prostaglandin H2 to prostacyclin (PGI2)VasodilationInhibition of platelet aggregation
04
Disease associations
Cardiovascular disease (e.g., myocardial infarction, stroke, atherosclerosis)Pulmonary arterial hypertensionInflammation and rheumatological diseases (e.g., rheumatoid arthritis)
05
Safety considerations
Bleeding risk due to inhibition of platelet aggregation
06
Interacting drugs
Epoprostenol (Flolan)
2 more in the full profile.
Beyond the preview
Go deeper on Prostaglandin I2 synthase (PTGIS).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Prostaglandin I2 synthase (PTGIS).