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Prostaglandin I3 (PGI₃)
- Target
- PGI₃
- Molecular classification
- Eicosanoid, Prostaglandin, Lipid mediator
01
Overview
Prostaglandin I3 (PGI₃) is an eicosanoid derived from eicosapentaenoic acid (EPA). It acts as an anti-aggregatory agent by inhibiting platelet aggregation and promoting vasodilation, thereby playing a protective role against thrombosis. Its synthesis is mediated by cyclooxygenase (COX) and prostacyclin synthase enzymes. PGI₃, similar to its analog PGI₂, counteracts the pro-aggregatory effects of thromboxane A₂ (TXA₂), contributing to cardiovascular protection.
- Other names
- Prostacyclin I3PGI3
02
Mechanism of action
Inhibits platelet aggregation by increasing intracellular cAMP levels, leading to reduced thrombus formation.
03
Biological functions
Inhibition of platelet aggregationVasodilationAnti-thrombotic
04
Disease associations
Cardiovascular diseaseThrombosisCoronary artery disease
05
Safety considerations
Excessive vasodilationPotential bleeding risk
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