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Prostaglandin Production Pathway
- Molecular classification
- Enzyme Pathway
01
Overview
The prostaglandin production pathway refers to the series of biochemical reactions that synthesize prostaglandins—autocrine and paracrine lipid mediators—from fatty acid precursors, primarily arachidonic acid. Prostaglandins are produced in most tissues and organs by almost all nucleated cells and play key roles in inflammation, pain signaling, vascular tone regulation, platelet aggregation, gastric mucosal protection, renal function, and reproductive processes.
02
Mechanism of action
Inhibition of cyclooxygenases (COX-1 and COX-2) or phospholipase A2 (PLA2).
03
Biological functions
InflammationPain signalingVascular tone regulationPlatelet aggregationGastric mucosal protectionRenal functionReproductive processesHomeostasis
04
Disease associations
InflammationPainCardiovascular diseaseRenal diseaseReproductive disorders
05
Safety considerations
Gastrointestinal side effects (NSAIDs)Cardiovascular risks (NSAIDs)Renal dysfunction (NSAIDs)
06
Interacting drugs
Aspirin
2 more in the full profile.
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